The comparative oncology program has the goal of drawing on key strengths of UC Davis in animal research pertaining to the disease mechanisms that are implicated in the genesis and progression of cancer.
Its themes, linked by the use of animal models, include (1) tumor biology and the mechanisms of carcinogenesis, (2) animal models of cancer, and (3) spontaneous cancers in large animals.
In pursuit of Theme 1, several investigators rely on a variety of animal models for investigating basic mechanisms of tumor biology, with emphases on oncogenes, tumor suppressor genes and cancer initiation and progression.
Areas of particular interest in Theme 2 include novel mouse models, phenotyping of onco-mice, cancer stem cells, anti-tumor immunity, and inflammation and cancer.
Theme 3 incorporates research on novel therapeutics imaging modalities, and cancer etiology.