CLH: 210Y / CRN: 58453 Principles and Methods of Comparative Effectiveness Research Spring 2020 Course
Welcome to the CER Course "Principles and Methods of Comparative Effectiveness Research"
This course will provide an introduction to a range of Comparative Effectiveness Research Methods. Set in a hybrid course format, students will review recorded lectures online, and complete assignments outside of class. There will be weekly 2-hour face-to-face meetings to discuss lecture content, review journal articles, and work on class projects.
About Spring 2020 Course
When: TBA
Where: TBA
Course Description: Comparative effectiveness research (CER) is the conduct and synthesis of research comparing the benefits and harms of different interventions and strategies to prevent, diagnose, treat, and monitor health conditions in “real world” settings. It is a priority for the physical and economic health of the nation. This course will provide an introduction to CER and methods for conducting CER. The course will cover four areas of research methodology:
- Design and Analysis of Randomized Clinical Trials
- Design and Analysis of Observational Studies and Large Datasets
- Research Synthesis, Systematic reviews, and Meta-analysis
- Economic Evaluations, Modeling, and Health Policy
Course Learning Objectives:
- Introduction to the principles of CER
- Familiarity with key areas of research methodology needed to conduct or collaborate in CER
Target Audience: Junior faculty, clinical fellows, postdoctoral fellows, and graduate students who are pursuing, or have an interest in pursuing, comparative effectiveness research.
Minimum Recommended Prerequisites: Familiarity with research methodology, and a course in introductory statistics.
Co-Instructors of Record: Joy Melnikow, M.D., M.P.H. and Jeffrey Hoch, Ph.D.
James Holmes, Jr. M.D.
Richard Kravitz, M.D, M.S.P.H.
Daniel Nishijima M.D.
Patrick Romano, M.D., M.A.S.
Daniel Tancredi, Ph.D.
Registration: Contact hs-chpr@ucdavis.edu
Enrollment is limited to 20 students. Prerequisite: Introduction Statistics Course.
NOTE: You will need the latest version of Flash player to view the presentations. Please note that you may need to adjust the volume while viewing the video clips in the presentations.
Lesson 2: History and Basic Elements of Randomized Clinical Trials
Lesson 3: Explanatory and Pragmatic Trials for CER
Lesson 4: Evidence Based Medicine, Heterogeneity of Treatment Effects, and the Trouble with Averages
Lesson 5: Outcomes Assessment in Clinical Trials
Lesson 6: Analyzing Data from Randomized Clinical Trials
Lesson 7: Clinical Trials Data Infrastructure, Management and Reporting
Please take a few moments to complete this short three question survey
Lesson 9: Use of Observational Data in CER Use of OSHPD Administrative Data
Lesson 11: Off-Pump vs. On-Pump Bypass Surgery
Lesson 12: Using National HCUP Data to Evaluate CE of Pediatric Empyema Treatments
Lesson 13: Managing Dependent & Independent Variables in Observational CER Studies
Lesson 14: Observational Studies for CER. How can they be made as good as RCTs?
Lesson 19: Rules for Economic Efficiency
Lesson 20: Approaches to Cost-effectiveness Modeling
Lesson 21: Estimating Health-Related Quality of Life for CEA
Lesson 22: Comparative Effectiveness Research in Health Policy Formulation
Please take a few moments to complete this short three question survey
"The CER course is a Hybrid format with on-line lectures, in class discussion and assignments. The course provides an introduction to a range of Comparative Effectiveness Research Methods. Candidates for the course have completed an Introduction to Statistics course and are enrolled in a graduate program or are post doctoral students. The course can be taken for credit or audited with instructor approval. Please contact Kirstin Truitt @ kgtruitt@ucdavis.edu or (916) 734-7918 to request enrollment in the course and/or to obtain a CRN."
Principles and Methods of Comparative Effectiveness Research
The development of this course was funded by an American Recovery & Reinvestment Act (ARRA) administrative supplement awarded to the University of California, Davis parent CTSA grant (UL1 RR024146) from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research.
The course, taught in four modules comprising 22 lessons, is taught by CHPR Director Joy Melnkow and other UC Davis faculty, and may be taken free of charge.
Other Useful Links
Patient Centered Outcomes Research Institute (PCORI)
AHRQ Effective Health Care (Main Page) How to Get Involved in the Effective Health Care (EHC) Program: A Concise Guide for Stakeholders
Commonwealth Fund -Comparative Effectiveness Research and Evidence-Based Decision Making Across Four Countries: The U.K., Germany, France, and Australia
HHS.Gov: Comparative Effectiveness Research Funding
NIH Implementation Plan for CER
AHRQ Implementation Plan for CER
NEJM Comparative Effectiveness and Healthcare Reform
Federal Coordinating Council for Compative Effectiveness Report
Comparative Effectiveness Research (CER) Useful Resources
Principles and Methods of Comparative Effectiveness Research
Patient Centered Outcomes Research Institute (PCORI)
AHRQ Effective Health Care (Main Page) How to Get Involved in the Effective Health Care (EHC) Program: A Concise Guide for Stakeholders
Commonwealth Fund -Comparative Effectiveness Research and Evidence-Based Decision Making Across Four Countries: The U.K., Germany, France, and Australia
HHS.Gov: Comparative Effectiveness Research Funding
NIH Implementation Plan for CER
AHRQ Implementation Plan for CER
NEJM Comparative Effectiveness and Healthcare Reform
Federal Coordinating Council for Compative Effectiveness Report