MIND Institute Clinical Trials and Research Studies
A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals with Fragile X Syndrome
The purpose of this study is to test the effects of metformin, a common type 2 diabetes medication. There is evidence that metformin is beneficial for language, cognitive development, and eating behavior in children and adults with FXS. If you participate in this study, you can expect three visits to the UC Davis MIND Institute over a four-month period. These visits will include cognitive, language, sensory, and social assessments administered by the MIND Institute team. The visits will also include medical appointments with Dr. Randi Hagerman, and all visits will have a blood draw for the participant. The study medication is currently available in capsule form and would need to be given twice daily. There are also phone calls during the four months to see how your child is doing in the study.
We are recruiting males and females, ages 6-25 who are diagnosed with Fragile X Syndrome.
Genotype-Phenotype Relationships in Fragile X Families (March 2017-February 2022)
This study aims to learn more about the fragile X premutation in older adults compared to those without. We will follow over 100 patients with FXTAS ages 55 to 75 in a prospective study to develop innovative clinical measures to identify areas of specific deficits and to identify biological markers for each stage of the. If you participate in this study, you can expect: 2-3 visits to the MIND Institute, which will include a medical history exam, neuropsychological evaluation, behavioral testing, neurological evaluation, balance and tremor assessments, MRI, blood draw, and skin biopsy
We are recruiting males and females with the premutation (ages 55-85 years) who are having symptoms of FXTAS.
Longitudinal Study of Brain and Cognition in Fragile X Premutation Carriers
This study examines changes in the brain and cognition associated with aging, in males with and without the fragile X premutation. The study consists of three 2-day visits over the course of five years to observe changes in the brain and cognition occurring over time. The protocol involves a medical history exam, neuropsychological evaluation, behavioral testing, MRI, and blood draw.
We are recruiting males (ages 45 years and over) with and without the premutation.
A Cognitive Test Battery for Intellectual Disabilities
for more information about this study.
The purpose of this research is to explore whether certain types of intellectual or cognitive tests are reliable, valid, and sensitive to improvement in evaluating treatment responses among individuals with intellectual disability. This newer cognitive test has been shown to accurately measure various cognitive skills across a wide age range, but has yet to be adapted and tested among individuals with intellectual disability. Participation in the study involves two to three visits at the UC Davis MIND Institute. The first visit will last approximately 3.5–4 hours and is scheduled over a two-day period. The second visit is scheduled approximately 4 weeks later and will be much shorter, only lasting about an hour. Some participants will be asked to return for a third visit. The schedule for the third visit is the same as the first visit and will take place approximately two years later. These visits will include cognitive testing for your son/daughter, and parents/guardian will be asked to fill out questionnaires. This is a multisite study with teams in Chicago and Denver also seeking participants.
We are recruiting individuals between the ages of 6–25 years old with a confirmed diagnosis of intellectual disability caused by fragile X syndrome, Down syndrome, or another cause.