Year One: The main emphasis is on acquisition of knowledge and insight in general principles of General Genetics and Biochemical Genetics. Residents participate in a wide variety of clinic opportunities including - General Genetics Clinics, Biochemical Genetics, NF/Ras Pathway, Craniofacial, Cardiovascular Genomics, Ocular Genomics, Precision Genomics, and rotates on the inpatient service at UC Davis Children's Hospital. Learners begin to develop critical skills in medical knowledge/care/management and the differential diagnosis, systems-based practice, communication skills/professionalism/team practice, and practice-based learning and improvement.
Year Two: The beginning of year two, the learner will have the basic fund of knowledge and practice to begin gaining autonomy in decision-making. By the second half of Year 2, the residents will have a solid knowledge base to independently formulate a differential diagnosis and manage the care of hospital-based patients. Elective clinics available to the resident including Neuromuscular Disease, Fragile X , 22q11 deletion syndrome and Huntington Disease.
Genomic Medicine Clinical Rounds – Weekly, multidisciplinary CME educational event designed to enhance provider practice and knowledge of Genomic Medicine. Participants will be kept abreast of topics in the rapidly changing field of clinical genomics through discussion of known and novel genetic/genomic conditions, clinical cases, next generation diagnostic genomic testing, treatment, therapies, and research.
UC Davis Human Genomics Seminar Series – Monthly, CME web-connected lecture series on various topics of Hyman Genomics. It serves as a forum for all learners, clinical and basic sciences, at both UC Davis Campuses.
UC Davis Annual Human Genomics Symposium - CME Symposium including the basic sciences, veterinary medicine human disease modeling, clinical translation, and clinical aspects of Human Genomics and Genomic Medicine. Participants include clinical and basic sciences personnel at both Campuses, and attendees from the Northern California region (including UCSF, Stanford, Kaiser, Cal State Stanislaus GC students, and physicians and GCs from Children’s Hospital Madera).
UC Davis Molecular Diagnostics Clinical Laboratory Rotation – Each resident spends 2 weeks learning molecular diagnostics under the supervision of Dr. Jeff Gregg in the Clinical Molecular Diagnostic Laboratory at UC Davis Medical Center and with Dr. Flora Tassone of the UC Davis MIND Institute Fragile X laboratory. While in the laboratory, the resident learns the technology associated with studies performed, including polymerase chain reaction, reverse dot blot, Southern blot, and restriction fragment length polymorphism analysis. The residents assist the Directors in interpreting abnormal results and conveying the results to referring physicians. The laboratory directors supervise all procedures. The residents have hands on experience with procedures and participate in all clinical and teaching didactics with the Pathology residents as well as attend Pathology Grand Rounds while on this rotation.
ARUP Biochemical Laboratory Rotation – In the first year, each of the residents spends 2 weeks in the Clinical Biochemical Genetics Laboratory at ARUP, the laboratory that UC Davis uses for all its biochemical [blood, urine] testing. The Director of the rotation is Dr. Marzia Pasquali, Section Chief, Biochemical Genetics and Medical Director, Biochemical Genetics and Newborn Screening. While in the laboratory, the resident learns the technology associated with the assays, the indications for the tests, normal values, and the meaning of abnormal results. They also assist the Laboratory Director in interpreting abnormal results and conveying results to referring physicians. Dr. Marzia Pasquali directly supervises all procedures. The residents have hands on experience with procedures and participate in all clinical and teaching conferences while in the laboratory. Additionally, the resident will attend all didactic lectures for learners which takes place on Wednesday during this rotation as well as formally present an interesting case during their final case review session in the rotation. Formal case review takes place on Fridays.
ARUP Cytogenetics and Genomic Microarray Rotation - Each of the residents spends 2 weeks in the Cytogenetics and Genomic Microarray Laboratory at ARUP, the laboratory that UC Davis uses for cytogenetic testing. The Director of the rotation is Dr. Bo Hong. While in the laboratory, the resident learns all stages of tissue culture and cytogenetic analyses. The resident helps preform molecular cytogenetics analysis of specimens, including rapid karyotypes, fluorescence in situ hybridization and chromosomal microarray. The resident assists the Director in interpreting abnormal results and conveying results to referring physicians. Dr. Bo Hong supervises all procedures. The residents have hands on experience with procedures and will attend all didactic lectures for learners during this rotation as well as formally present an interesting case during their final didactic session in the rotation. Didactics take place every Wednesday and formal case review takes place every Friday. While on this rotation, residents will learn about the laboratory aspect of and participate in Next Generation Sequencing (NGS) testing and analyses. During this rotation, the Medical Genetics residents will also learn the laboratory fundamentals of NGS such as panel gene testing and exome testing. The Molecular laboratory at ARUP is in close vicinity to the Clinical Cytogenetics and Genomic Microarray Laboratory under the direction of Dr. Yuan Ji, Medical Director of the Molecular Genetics and Genomics Lab. While in the laboratory, the resident learns the processing for NGS, how sequencing is performed and is introduced to the complex analysis of sequencing data. The resident will learn about software analysis and interpreting variants of unknown significance.