Publications

Research grants

Financial Resources for Diana L. Farmer (PI)

Funding Agency Name: Shriners Hospital Northern California

Project Number: 8512 (Farmer)

Project Title: Early Gestation Placental Mesenchymal Stromal Cells for the Treatment of Spina Bifida –long term effects

Status of Support: Active

Role on Project: PI

Percent Time on Project: 5 percent

Total Award (for all years): 810,602.00

Project Dates: Start: 01/01/16, Finish: 12/31/2019

Aims of the Project
Determine the long-term efficacy, clinical outcomes, and possible mechanisms of action of PMSC treatment in the fetal lamb model of SB.

This project examines motor function and kinetics, radiographs and MRI, as well as bowel and bladder assessment. Lambs will be survived. All separate animals are utilized. These experiments will evaluate the long term (>48hrs.) therapeutic effectiveness of PMSCs on the complications associated with spina bifida. None of these metrics are contained within the CIRM proposal. No overlapping experiments are contained within the CIRM proposal. Furthermore, a portion of the CIRM in-vitro milestones center on the establishment of a neuroprotective potency assay. No potency assays are developed in the Shriners proposal.

Metrics of neuropathology and cellular retention are wholly unique to the Shriners proposal. No overlapping experiments are contained within the CIRM proposal.

Areas of Potential Scientific or Budgetary Overlap: None

Proposed Overlap Resolution (if there is any overlap): N/A

Funding Agency Name: Shriners Hospital Northern California

Project Number: 87410 (Wang)

Project Title: Developing guinea pigs as a cost-effective high throughput model of spina bifida

Status of Support: Active

Role on Project: Co-I

Percent Time on Project: 5 percent

Total Award (for all years): $119,903

Project Dates: Start: 01/01/17, Finish: 12/31/2018

Aims of the Project
The major goal of this project is to develop guinea pigs as a cost-effective high throughput model of fetal treatment of spina bifida for evaluation of new therapies. Based on our previous studies, we are using this model to evaluate the therapeutic effect of using novel scaffolds designed to illicit bone growth in the boney defect of spina bifida. Xenogeneic human PMSCs will be transplanted in utero to the guinea pig model of spina bifida in this study. These experiments are not described in the CIRM proposal.

Areas of Potential Scientific or Budgetary Overlap: None

Proposed Overlap Resolution (if there is any overlap): N/A

Funding Agency Name: NIH

Project Number: 1R01NS100761 (Wang)

Project Title: Fetal Tissue Engineering to Treat Spina Bifida Before Birth

Status of Support: Active

Role on Project: Co-I

Percent Time on Project: 5 percent

Total Award (for all years): $1,093,750

Project Dates: Start: 08/01/17, Finish: 04/30/2022

Aims of the Project
The major goal of this project is to develop a multifunctional, bioengineered scaffold for fetal treatment of spina bifida to provide neuroprotection, anti-tethering and bone regeneration functions simultaneously. Multiple biomaterial-based osteogenic scaffolds will be evaluated in the in vitro cell culture model. Fetal spina bifida animal models of rats, rabbits and sheep will be used to evaluate the neuroprotection, anti-tethering and bone regeneration functions of the bioengineered scaffolds. These experiments are not described in the CIRM proposal.

Areas of Potential Scientific or Budgetary Overlap: None

Proposed Overlap Resolution (if there is any overlap): N/A

Funding Agency Name: NIH

Project Number: R03HD091601 (Wang)

Project Title: Guinea pigs as a model of in utero stem cell therapy for spina bifida

Status of Support: Active

Role on Project: Co-I

Percent Time on Project: 5 percent

Total Award (for all years): $100,000

Project Dates: Start: 07/01/17, Finish: 06/30/2019

Aims of the Project
The major goal of this project is to derive and characterize placental mesenchymal stem cells from guinea pigs (gpPMSCs) and transplant them for in utero treatment of spina bifida in the guinea pig model. Since guinea pigs are highly inbred, gpPMSCs will be used as autologous cells and their therapeutic functions will be evaluated for in utero treatment of spina bifida. These experiments are not described in the CIRM proposal.

Areas of Potential Scientific or Budgetary Overlap: None

Proposed Overlap Resolution (if there is any overlap): N/A

Financial Resources for Aijun Wang (PI)

Funding Agency Name: Shriners Hospital Northern California

Project Number: 8512 (Farmer)

Project Title: Early Gestation Placental Mesenchymal Stromal Cells for the Treatment of Spina Bifida – long term effects

Status of Support: Active

Role on Project: Co-PI

Percent Time on Project:  15 percent

Total Award (for all years): 810,602.00

Project Dates: Start: 01/01/16, Finish: 12/31/2019

Aims of the Project:Described above in PI section

Areas of Potential Scientific or Budgetary Overlap: None. Described above in PI section

Proposed Overlap Resolution (if there is any overlap): N/A

Funding Agency Name: Shriners Hospital Northern California

Project Number: 87410 (Wang)

Project Title: Developing guinea pigs as a cost-effective high throughput model of spina bifida

Status of Support: Active

Role on Project: PI

Percent Time on Project: 5 percent

Total Award (for all years): $119,903

Project Dates: Start: 01/01/17, Finish: 12/31/2018

Aims of the Project:Described above in PI section.

Areas of Potential Scientific or Budgetary Overlap:  None

Proposed Overlap Resolution (if there is any overlap): N/A

Funding Agency Name: NIH

Project Number: 1R01NS100761 (Wang)

Project Title: Fetal Tissue Engineering to Treat Spina Bifida Before Birth

Status of Support: Active

Role on Project: PI

Percent Time on Project: 30 percent

Total Award (for all years): $1,093,750

Project Dates: Start: 08/01/17, Finish: 04/30/2022

Aims of the Project: Described above in PI section.

Areas of Potential Scientific or Budgetary Overlap: None

Proposed Overlap Resolution (if there is any overlap): N/A

Funding Agency Name: NIH

Project Number: R03HD091601 (Wang)

Project Title: Guinea pigs as a model of in utero stem cell therapy for spina bifida

Status of Support: Active

Role on Project: PI

Percent Time on Project: 5 percent

Total Award (for all years): $100,000

Project Dates: Start: 07/01/17, Finish: 06/30/2019

Aims of the Project: Described above in PI section.

Areas of Potential Scientific or Budgetary Overlap:  None

Proposed Overlap Resolution (if there is any overlap): N/A